of Sodium Copper Chlorophyllin (SCC) in Somatic Cells of Drosophila melanogaster Pimentel, E., Cruces, M.P., Zimmering, S. On the persistence of the. Sodium Copper Chlorophyllin (SCC) Induces Genetic Damage in Postmeiotic and Somatic Wing Cells of Drosophila melanogaster. Martha Patricia Cruces at National Institute of Nuclear Research, Mexico · Martha Patricia Drosophila melanogaster deficient in endogenous.

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Ferrochelatase could participate in the chelating chromium, provoking a reduction in mealnogaster mutagenic effect. The table expresses the mean of three experiments. Unrestricted non-commercial use is permitted provided the original work is drsoophila cited. The Biological Chemistry of the Elements. One side statistical tests. Interaction of porphyrin and metalloporphyrin excited states with molecular oxygen.

Instructors can set the parameters for the populations under study, such as the number and type of traits in a population, the modes of inheritance and trait linkage.

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Click here to launch CGS in a new window. When a genetic alteration is induced in a mitotically dividing cell of a developing imaginal wing disc, it may give rise to a group of mutant cells spots easily recognizable on the adult wing blade. The wing spot test was used. Early experiments conducted in the lab of Thomas Morgan uncovered many interesting Drosophila phenotypes ,which greatly advanced our knowledge of genetic inheritance.


Photodynamic therapy with endogenous protoporphyrin IX: Disclosures and Ethics As a requirement of publication author s have provided to the publisher signed confirmation of compliance with legal and ethical obligations including but not limited to the following: It was suggested that copper could associate with proteins and participate in anabolic homeostatic pathways. Not only are workers in manufacturing industries exposed to chromium compounds, but also the general public is exposed through cigarette smoke, automobile emissions, landfills, and hazardous waste disposal sites [12].


The wings were examined to identify small single spots one or two cellslarge single spots more than two cells of either mwh or flrand mwh-flr twin spots. The analysis showed that PP-IX was nontoxic at the three concentrations tested compared to the control.

Evidence indicates that the hexavalent form is mutagenic and carcinogenic. Cruces1 and Stanley Zimmering 2. Advances in metal-induced oxidative stress and human disease.

Among heavy metals, chromium is considered one of the most dangerous and the International Agency of Research on Cancer [6] recognized the carcinogenicity of this metal.

Drosophila Genetics Simulation

All authors reviewed and approved of the final manuscript. Chlorophyllin as protector of mitochondrial membranes against gamma-radiation and photosensitization.

Purification and substrate specificity of bovine liver-ferrochelatase. The crucial role of copper in the antimutagenicity of porphyrins was demonstrated earlier by Arimoto, 17 who found that the metal-free porphyrins in Salmonella had only a minor antimutagenic effect as compared with those in which an appropriate metal was present. The different studies on the role of ferrochelatase have revealed that this enzyme catalyzes zinc as well as the iron chelating activity of protoporphyrin [14].

Ferguson LR, Philpott M. All treatments were conducted in the dark. National Center for Biotechnology InformationU. The objective of the current research was to compare the antimutagenic effects of two SCC compounds with different amounts of copper 3.

Improving regioselectivity in the rhodium catalyzed hydroformylation of protoporphyrin-IX and chlorophyll a derivatives. Competing Interests Author s disclose no potential conflicts of interest. Table 1 shows the frequency of all kinds of spots induced by the different concentrations of CrO 3.

The wings were examined to identify small single spots one or two cellslarge single spots more than two cells of either mwh or flrand mwh-flr twin spots. Finally, the extent of the inhibitory effect of SCC reported in different publications 11 may have resulted from differences in the copper content of commercial SCC compounds.


Evidence that chlorophyllin CHLN may behave as an inhibitor or a promoter of radiation-induced genetic damage in somatic cells of. The results indicated that the lower PP-IX concentration 0. Absence of an inhibitor effect of PP-IX against 20 Gy gamma rays suggested that this porphyrin acted primarily by forming complexes with chromium at low doses, inactivating its genotoxic action rather than capturing or inactivating the reactive oxygen species generated by the chromium. In view of those finding, and due to the association of SCC with a variety of uses in humans, perhaps notably as a chemo preventive agent and food supplement, this should demand, if not in practice as yet, greater attention to the different concentration of copper in the SCC products in use.

The test uses the wing-cell recessive markers multiple wing hairs mwh3—0. Oviposition was restricted to a 2 h period so as to obtain more homogeneous samples in the age of individuals under test. However, the evidence found in this study indicated that in organisms pretreated with PP-IX and subsequently treated with CrO 3the frequency of genetic damage was reduced in most of the treated groups. Evidence that low concentrations of chlorophyllin CHLN increase the genetic damage induced by gamma rays in somatic cells of.